Intraovarian Platelet-Rich Plasma (PRP) Therapy is a cutting-edge medical procedure that utilizes the healing properties of platelet-rich plasma to improve ovarian function and potentially enhance fertility. PRP is derived from the patient’s own blood and contains a high concentration of platelets, growth factors, and other bioactive substances that stimulate tissue regeneration and repair.
During the Intraovarian PRP Therapy procedure, a small amount of blood is drawn from the patient. The blood is then processed in a centrifuge to separate the platelets and plasma from other blood components. The resulting platelet-rich plasma is carefully injected into the ovaries under ultrasound guidance. The growth factors and bioactive substances in PRP help to promote the regeneration of ovarian tissue, improve blood flow, and potentially enhance the ovarian response.
Intraovarian PRP Therapy may also be useful in patients with diminished ovarian reserve and premature ovarian failure.
Improved ovarian function: PRP therapy may help to rejuvenate the ovaries1, promoting healthier and more optimal egg production. Studies, and our experience have shown an increased antral follicle count, and improved ovarian function.
Enhanced fertility: By stimulating the growth and development of ovarian follicles, PRP therapy may improve fertility and increase the chances of successful conception, by promoting the growth of more eggs in the ovaries2.
Increased response to ovarian stimulation: In individuals undergoing assisted reproductive techniques such as in vitro fertilization (IVF), Intraovarian PRP Therapy may improve the response to ovarian stimulation medications, leading to a higher number of mature eggs for retrieval3.
Intraovarian PRP Therapy is a safe procedure and involves injecting plasma into the ovaries, using the same equipment used for egg retrieval during an IVF procedure. Since PRP is derived from the patient’s own blood, there is minimal risk of adverse reactions or complications. However, as with any medical procedure, there may be slight risks involved, such as infection or temporary discomfort at the injection site.
Despite the above noted potential benefits, it should be noted that this is a recent introduced procedure, and wide experience is still lacking. Large randomized controlled trials (gold standard evidence) of the benefits of the therapy are still lacking.
The Intraovarian PRP Therapy procedure typically involves the following steps:
Blood draw: A small amount of blood is withdrawn, like a routine blood test.
PRP preparation: The blood sample is processed using a centrifuge to separate the platelet-rich plasma from other blood components.
PRP injection: Using ultrasound guidance for precision, the PRP is carefully injected into the ovaries.
The procedure’s duration may vary, but it is typically completed within one to two hours.
The recovery process after Intraovarian PRP Therapy is minimal. It is advised to rest on the day of the procedure.
Please contact Oasis Fertility Center for further details of the schedule of treatments, and other information.
1. Garavelas A, Mallis P, Michalopoulos E, et al. Clinical Benefit of Autologous Platelet-Rich Plasma Infusion in Ovarian Function Rejuvenation: Evidence from a Before-After Prospective Pilot Study. Medicines (Basel) 2023;10(3).
2. Merhi Z, Seckin S, Mouanness M. Intraovarian platelet-rich plasma administration could improve blastocyst euploidy rates in women undergoing in vitro fertilization. Clin Exp Reprod Med 2022;49(3):210-14.
3. Melo P, Navarro C, Jones C, et al. The use of autologous platelet-rich plasma (PRP) versus no intervention in women with low ovarian reserve undergoing fertility treatment: a non-randomized interventional study. J Assist Reprod Genet 2020;37(4):855-63.
